A new mechanism for blocking myeloid-derived suppressor cells by CpG.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21288925.
- Also identified by DOI 10.1158/1078-0432.CCR-11-0024 and PMC identifier 4237605.
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Abstract
In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.
Medical subject headings
- Antineoplastic Agents
- DNA
- Immune Tolerance
- Myeloid Cells
- Neoplasms
- Toll-Like Receptor 9