An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21295269.
- Also identified by DOI 10.1016/j.stem.2011.01.010.
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Abstract
In a recent Nature paper, Itzhaki et al. (2011) generate induced pluripotent stem cells (iPSCs) from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2. Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac electrical signatures of the disease, which can be reversed by pharmacological intervention.
Medical subject headings
- Induced Pluripotent Stem Cells
- Myocytes, Cardiac