Cell migration: GSK3β steers the cytoskeleton's tip.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21295692.
- Also identified by DOI 10.1016/j.cell.2011.01.023 and PMC identifier 3929416.
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Abstract
Directed cell migration polarizes the cytoskeleton, allowing the cell to move toward migratory cues. In this issue, Wu et al. (2011) demonstrate that the glycogen synthase kinase 3β (GSK3β) controls microtubule architecture and polarized movement of skin stem cells during wound healing in mammals by regulating the microtubule crosslinking protein ACF7.