A versatile sugar transferase makes the cut.
basic_science · Level V
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- Record sourced from PubMed, PMID 21295693.
- Also identified by DOI 10.1016/j.cell.2011.01.025 and PMC identifier 10494360.
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Abstract
The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.