Pharmacogenetics: Anti-TNF therapy in RA--towards personalized medicine?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 21304506.
- Also identified by DOI 10.1038/nrrheum.2011.13.
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Abstract
A substantial proportion of patients with rheumatoid arthritis do not respond to tumor necrosis factor blocking therapy. Results of a large genome-wide association study demonstrate evidence of novel genetic factors that determine response to treatment, which could provide a basis for individualizing therapy.
Medical subject headings
- Arthritis, Rheumatoid
- Pharmacogenetics
- Precision Medicine
- Tumor Necrosis Factor-alpha