Anaphylactic reaction after methylene blue-treated plasma transfusion.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 21310720.
- Also identified by DOI 10.1093/bja/aer009.
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Abstract
Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate allergic hypersensitivity reaction to methylene blue-treated plasma transfusion. The clinical course and subsequent assessment of the allergic reaction, including skin tests and basophil activation test, confirmed methylene blue-induced IgE-mediated anaphylaxis. All immediate reactions after MB-FFP transfusion should be investigated to document the underlying mechanism.
Medical subject headings
- Anaphylaxis
- Methylene Blue
- Plasma