A skin-contact-actuated micropump for transdermal drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21317070.
- Also identified by DOI 10.1109/TBME.2011.2113347.
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Abstract
In this paper, a skin-contact-actuated dispenser/micropump for transdermal drug delivery applications is presented. The micropump consists of stacked polydimethylsiloxane layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low-boiling-point liquid. Therefore, there is no need for a heater and a power source, since only the thermal energy provided by skin contact is required for the actuation. A prototype device with overall dimensions of 14 mm × 14 mm × 8 mm is fabricated and characterized. For a perfluoro compound working fluid (3M FC-3284), a flow rate of 28.8 μ L/min and a maximum back pressure of 28.9 kPa is measured.
Medical subject headings
- Administration, Cutaneous
- Infusion Pumps
- Microfluidics
- Skin Physiological Phenomena