DNA-functionalized nanochannels for SNP detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21323380.
- Also identified by DOI 10.1021/nl200357y.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have developed ultrahigh density array of functionalized nanochannels by using a block copolymer having end di-COOH group. This approach provides a facile route for direct functionalization of wall surface of the nanochannels and immobilization site for molecular recognition agents (MRAs). By using overhanging single-stranded DNA as MRAs, the DNA-functionalized nanochannels showed high resolution to detect a single-base mismatch as well as to discriminate single-mismatched sequence at various locations by hybridization preference with MRAs.
Medical subject headings
- DNA
- Nanostructures
- Polymorphism, Single Nucleotide