Engaging neuroscience to advance translational research in brain barrier biology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21331083.
- Also identified by DOI 10.1038/nrn2995 and PMC identifier 3335275.
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Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Medical subject headings
- Blood-Brain Barrier
- Nervous System Diseases
- Neurosciences
- Translational Research, Biomedical