Targeting aneuploidy for cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21335229.
- Also identified by DOI 10.1016/j.cell.2011.01.037.
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Abstract
Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?