Genetic control of hepatitis A severity and susceptibility to allergy.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21339636.
- Also identified by DOI 10.1172/JCI46418 and PMC identifier 3049371.
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Abstract
Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the JCI, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor--TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.
Medical subject headings
- Genetic Predisposition to Disease
- Hepatitis A
- Hypersensitivity