Unraveling virus-induced lymphomagenesis.
other · Level V
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- Record sourced from PubMed, PMID 21339638.
- Also identified by DOI 10.1172/JCI46499 and PMC identifier 3046640.
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Abstract
Kaposi sarcoma herpesvirus (KSHV), a human gammaherpesvirus, is the etiological agent for the endothelial-derived Kaposi sarcoma (KS) and also for certain lymphoproliferative disorders. In these lymphoproliferations, the KSHV-infected cells carry the stigmata of B lymphocytes, with plasmablastic features. The JCI has published three manuscripts addressing key questions related to B cell infection and viral latent expression in B cells. Myoung and Ganem provide evidence that CD4(+) lymphocytes suppress KSHV replication, promoting latency in B cells; Hassman and colleagues show that KSHV infection drives plasmablast differentiation in a subset of IgM(+) λ light chain-expressing cells; and Ballon and colleagues describe the in vivo transdifferentiation of B lymphocytes by KSHV-encoded viral FLICE-inhibitory protein (vFLIP).
Medical subject headings
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Herpesvirus 8, Human