R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.
basic_science · Level V
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- Record sourced from PubMed, PMID 21349869.
- Also identified by DOI 10.1093/bioinformatics/btr102.
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Abstract
The R453Plus1Toolbox is an R/Bioconductor package for the analysis of 454 Sequencing data. Projects generated with Roche's data analysis software can be imported into R allowing advanced and customized analyses within the R/Bioconductor environment for sequencing data. Several methods were implemented extending the current functionality of Roche's software. These extensions include methods for quality assurance and annotation of detected variants. Further, a pipeline for the detection of structural variants, e.g. balanced chromosomal translocations, is provided. The R453Plus1Toolbox is implemented in R and available at http://www.bioconductor.org/. A vignette outlining typical workflows is included in the package. h.klein@uni-muenster.de Supplementary data are available at Bioinformatics online.
Medical subject headings
- Sequence Analysis, DNA
- Software