The MEMPACK alpha-helical transmembrane protein structure prediction server.
basic_science · Level V
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- Record sourced from PubMed, PMID 21349872.
- Also identified by DOI 10.1093/bioinformatics/btr096 and PMC identifier 3087951.
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Abstract
The experimental difficulties of alpha-helical transmembrane protein structure determination make this class of protein an important target for sequence-based structure prediction tools. The MEMPACK prediction server allows users to submit a transmembrane protein sequence and returns transmembrane topology, lipid exposure, residue contacts, helix-helix interactions and helical packing arrangement predictions in both plain text and graphical formats using a number of novel machine learning-based algorithms. The server can be accessed as a new component of the PSIPRED portal by at http://bioinf.cs.ucl.ac.uk/psipred/.
Medical subject headings
- Algorithms
- Artificial Intelligence
- Membrane Proteins