Endothelium-dependent delivery of insulin to muscle interstitium.
basic_science · Level V
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- Record sourced from PubMed, PMID 21356512.
- Also identified by DOI 10.1016/j.cmet.2011.02.008 and PMC identifier 3232062.
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Abstract
Insulin contributes to skeletal muscle glucose uptake by increasing blood flow and recruiting perfused capillaries. In this issue of Cell Metabolism, Kubota et al. (2011) show that deletion of IRS-2 in endothelial cells in mice causes impaired transcapillary insulin transport, decreased insulin-stimulated glucose uptake in muscle, and mild glucose intolerance.