Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21356514.
- Also identified by DOI 10.1016/j.cmet.2011.02.004 and PMC identifier 3062104.
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Abstract
The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.
Medical subject headings
- Lipid Metabolism
- MicroRNAs
- Sterol Regulatory Element Binding Protein 2