Non-HLA antibodies in kidney allograft rejection: convincing concept in need of further evidence.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21358654.
- Also identified by DOI 10.1038/ki.2010.517.
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Abstract
Mostly indirect evidence suggests an important pathogenic role for non-HLA anti-endothelial cell antibodies (AECAs) in both acute and chronic rejection. The lack of standardized screening assays for AECAs unfortunately hampers the systematic collection of data in multicenter trials. Diagnostic tests based on commercially available platforms could pave the way for testing larger patient cohorts, but they still suffer from some important limitations.
Medical subject headings
- Autoantibodies
- Endothelial Cells
- Graft Rejection
- Graft Survival
- Kidney Transplantation