Iodine deficiency in northern Paris area: impact on fetal thyroid mensuration.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21359193.
- Also identified by DOI 10.1371/journal.pone.0014707 and PMC identifier 3040245.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography. RESULTS: We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02). CONCLUSION: Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539.
Medical subject headings
- Iodine
- Pregnancy Complications
- Thyroid Diseases
- Thyroid Gland