Safely modulating the immune system in regenerative medicine.
editorial · Level V
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- Record sourced from PubMed, PMID 21362563.
- Also identified by DOI 10.1016/j.stem.2011.02.013.
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Abstract
The destruction of pluripotent stem cell-derived grafts by the host immune system presents a significant barrier to clinical translation of cell therapies. Pearl et al. (2011) report in this issue of Cell Stem Cell that a brief, nontoxic immunosuppressive regimen, achieved by blockade of leucocyte costimulatory pathways, may overcome this problem.