Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21364910.
- Also identified by DOI 10.1371/journal.pone.0016580 and PMC identifier 3045367.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models.
Medical subject headings
- Computational Biology
- Evolution, Molecular
- Insulin Receptor Substrate Proteins
- Multigene Family