Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21364978.
- Also identified by DOI 10.1371/journal.pone.0015190 and PMC identifier 3043005.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody-driven antigenic variation in one domain of the H1 hemagglutinin Sa site leads to compensatory mutations in NA, resulting in NA antigenic variation and acquisition of drug resistance. These findings indicate that influenza A virus resistance to NA inhibitors can potentially arise from antibody driven HA escape, confounding analysis of influenza NA evolution in nature.
Medical subject headings
- Antibodies, Viral
- Antigenic Variation
- Drug Resistance, Viral
- Hemagglutinins
- Immune Evasion
- Influenza A virus
- Neuraminidase