The ribosome and TORC2: collaborators for cell growth.
review · Level V
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- Record sourced from PubMed, PMID 21376227.
- Also identified by DOI 10.1016/j.cell.2011.02.029 and PMC identifier 3285269.
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Abstract
The target of rapamycin complex 2 (TORC2) is a key regulator of cell growth. Zinzalla et al. (2011) now provide evidence that TORC2 is activated by direct association with the ribosome, which may ensure that TORC2 activity is calibrated to match the cell's intrinsic growth capacity.