The skeleton: the new controller of male fertility?

Smith, Lee B; Saunders, Philippa T K · Cell · 2011

basic_science · Level V

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Abstract

Sex steroids, including testosterone, regulate the development and function of the male skeleton. Oury et al. (2011) identify a surprising new connection between the skeleton and the testis, which has implications for male fertility. They show that testosterone production in the testis is directly influenced by the bone-derived hormone osteocalcin.