A bioinformatic assay for pluripotency in human cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21378979.
- Also identified by DOI 10.1038/nmeth.1580 and PMC identifier 3265323.
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Abstract
Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.
Medical subject headings
- Computational Biology
- Gene Expression Profiling
- Pluripotent Stem Cells