Nuclear magnetic resonance analysis of protein-DNA interactions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21389020.
- Also identified by DOI 10.1098/rsif.2010.0543 and PMC identifier 3119875.
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Abstract
Recent methodological and instrumental advances in solution-state nuclear magnetic resonance have opened up the way to investigating challenging problems in structural biology such as large macromolecular complexes. This review focuses on the experimental strategies currently employed to solve structures of protein-DNA complexes and to analyse their dynamics. It highlights how these approaches can help in understanding detailed molecular mechanisms of target recognition.
Medical subject headings
- DNA
- DNA-Binding Proteins
- Magnetic Resonance Spectroscopy