Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21395967.
- Also identified by DOI 10.1111/j.1474-9726.2010.00668.x and PMC identifier 3079202.
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Abstract
Those mice whose skin-derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age-related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.
Medical subject headings
- Aging
- Fibroblasts
- Hearing Loss
- Oxidants
- Skin
- Ultraviolet Rays