A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
case_control · Level III
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- Record sourced from PubMed, PMID 21402545.
- Also identified by DOI 10.1093/infdis/jiq154 and PMC identifier 3068033.
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Abstract
A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
Medical subject headings
- HLA-DP Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Viral Load