Investigation into the presence of and serological response to XMRV in CFS patients.
Where this comes from
- Record sourced from PubMed, PMID 21408077.
- Also identified by DOI 10.1371/journal.pone.0017592 and PMC identifier 3052320.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.
Medical subject headings
- Fatigue Syndrome, Chronic
- Xenotropic murine leukemia virus-related virus