Renaturation of denatured lambda repressor requires heat shock proteins.
basic_science · Level V
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Abstract
The temperature-sensitive bacteriophage lambda cI857 repressor protein rapidly renatures after thermal inactivation. E. coli mutants in the heat shock protein genes dnaK, dnaJ, and grpE do not efficiently reactivate heat-denatured repressor. Our results suggest that protein refolding is promoted by heat shock proteins and that such a process is the basis of the homeostatic role played by these proteins in the heat shock response.
Medical subject headings
- Bacteriophage lambda
- DNA-Binding Proteins
- Escherichia coli
- Heat-Shock Proteins
- Repressor Proteins
- Transcription Factors