Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH.
case_report · Level V
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- Record sourced from PubMed, PMID 21411780.
- Also identified by DOI 10.1309/AJCPZ1O7UUUISPNR.
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Abstract
Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma.
Medical subject headings
- Basal Cell Carcinoma
- Carcinoma, Basosquamous
- Carcinoma, Squamous Cell
- Carcinosarcoma
- Comparative Genomic Hybridization
- Esophageal Neoplasms