Interactome networks and human disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21414488.
- Also identified by DOI 10.1016/j.cell.2011.02.016 and PMC identifier 3102045.
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Abstract
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
Medical subject headings
- Disease
- Metabolic Networks and Pathways
- Proteins