Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21419480.
- Also identified by DOI 10.1016/j.jaci.2011.01.048 and PMC identifier 3121922.
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Abstract
Some, but not all, TACI mutations found in CVID impair TACI function and may potentially contribute to B cell dysfunction in heterozygotes via haploinsufficiency.
Medical subject headings
- Common Variable Immunodeficiency
- Signal Transduction
- Transmembrane Activator and CAML Interactor Protein