Impact of local versus global ligand density on cellular adhesion.
basic_science · Level V
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- Record sourced from PubMed, PMID 21425841.
- Also identified by DOI 10.1021/nl104079r and PMC identifier 3806292.
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Abstract
α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.
Medical subject headings
- Cell Adhesion
- Coated Materials, Biocompatible
- Fibroblasts
- Integrin alphaVbeta3