Insulin receptor activation in deletion 11q chronic lymphocytic leukemia.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21427241.
- Also identified by DOI 10.1158/1078-0432.CCR-11-0295.
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Abstract
The chromosomal abnormalities characteristic of chronic lymphocytic leukemia (CLL) are well studied, but the mechanisms underlying their contribution to pathogenesis are only partially elucidated. Integrated genomic profiling, focused on deletion 11q, has identified elevated expression of the insulin receptor in a subgroup of CLLs and associated it with worse outcomes.
Medical subject headings
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Leukemia, Lymphocytic, Chronic, B-Cell
- Receptor, Insulin