Influence of donor cytomegalovirus (CMV) status on severity of viral reactivation after allogeneic stem cell transplantation in CMV-seropositive recipients.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 21427386.
- Also identified by DOI 10.1093/cid/cir002.
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Abstract
We investigated the role of donor cytomegalovirus (CMV) serostatus on reactivation of CMV infection in CMV-infected transplant recipients. Reactivation of CMV infection occurred more frequently in patients receiving a CMV-positive graft but was less severe than in patients receiving a CMV-negative graft. These data suggest roles for both virus as well as CMV-specific immunity present in the graft.
Medical subject headings
- Cytomegalovirus
- Cytomegalovirus Infections
- Severity of Illness Index
- Stem Cell Transplantation
- Tissue Donors
- Virus Activation