Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 21427401.
- Also identified by DOI 10.1093/cid/cir072 and PMC identifier 3106234.
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Abstract
The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.
Medical subject headings
- HIV Infections
- HIV-1
- Receptors, HIV
- Viral Tropism
- Virology
- Virus Attachment