Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21439625.
- Also identified by DOI 10.1016/j.jaci.2011.02.035 and PMC identifier 3129393.
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Abstract
Peanut sensitization in diacylglycerol kinase zeta (DGKζ) deficient mice led to elevated peanut-IgE levels and severe anaphylaxis. DGKζ deficient CD4<sup>+</sup>T cells did not account for the phenotype. Future studies will determine which immune lineage caused increased food hypersensitivity.
Medical subject headings
- Diacylglycerol Kinase
- Peanut Hypersensitivity
- T-Lymphocytes