Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21451535.
- Also identified by DOI 10.1038/ki.2010.559 and PMC identifier 3677185.
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Abstract
Insufficient insulin secretion and insulin resistance are hallmarks of diabetes. Recent studies indicate that insulin plays an important role in maintaining the glomerular filtration barrier. Mima et al. report that glomeruli of diabetic and obese rats suffer from insulin resistance and altered insulin signaling. Protein kinase C inhibitors are able to overcome insulin resistance, offering new hopes for the treatment of the condition.
Medical subject headings
- Diabetic Nephropathies
- Insulin
- Kidney Glomerulus