Skin pigmentation from clofazimine therapy in leprosy patients: a reappraisal.
case_report · Level V
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Abstract
Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.
Medical subject headings
- Clofazimine
- Drug Eruptions
- Leprosy, Lepromatous
- Pigmentation Disorders