The origin of neuroendocrine tumors and the neural crest saga.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21455201.
- Also identified by DOI 10.1038/modpathol.2010.166.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this essay, the role of the neural crest in the development of the vertebrate embryo is briefly described. The techniques used to document the neural crest origin of various cell types and the tumors arising from them are discussed, with emphasis on Le Douarin's quail-chick chimera model. The current dogma on the origin of the cells of the diffuse endocrine system is presented, and some personal conjectures based on the microscopic appearances of various types of normal, vestigial and neoplastic human tissues are offered to the reader as 'food for thought.'
Medical subject headings
- Endocrine System
- Nervous System
- Neural Crest
- Neuroendocrine Tumors