Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?
Level V
Where this comes from
- Record sourced from PubMed, PMID 21455249.
- Also identified by DOI 10.1038/nrrheum.2011.28.
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Abstract
Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.
Medical subject headings
- Arthritis, Rheumatoid
- Autoantibodies
- Genetic Predisposition to Disease
- Peptides, Cyclic