Directly observing therapy: a new view of drug tolerance in tuberculosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 21458661.
- Also identified by DOI 10.1016/j.cell.2011.02.041.
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Abstract
Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.