Traveling Bax and forth from mitochondria to control apoptosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 21458662.
- Also identified by DOI 10.1016/j.cell.2011.03.025 and PMC identifier 3072571.
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Abstract
Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-induced permeabilization of mitochondria.