A one and a two … expanding roles for poly(ADP-ribose) polymerases in metabolism.
basic_science · Level V
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- Record sourced from PubMed, PMID 21459317.
- Also identified by DOI 10.1016/j.cmet.2011.03.011 and PMC identifier 3104020.
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Abstract
In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD(+) levels or by promoting SIRT1 expression.