Glucose as a mitogenic hormone.
basic_science · Level V
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- Record sourced from PubMed, PMID 21459319.
- Also identified by DOI 10.1016/j.cmet.2011.03.014.
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Abstract
Glucose stimulates insulin secretion in β cells, which sense glucose concentrations through signals derived from glycolytic metabolism. In this issue of Cell Metabolism, Dor and colleagues (Porat et al., 2011) combine genetic, transplantation, and pharmacologic approaches to show that glucose also stimulates β cell proliferation through similar metabolic signals, providing a new framework to develop therapeutics for diabetes.