The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21463460.
- Also identified by DOI 10.1111/j.1474-9726.2011.00711.x and PMC identifier 3135752.
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Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Dynamins
- Insulin