Adult survivors of invasive pneumococcal disease exhibit defective B cell function.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 21467018.
- Also identified by DOI 10.1093/cid/cir126 and PMC identifier 3106266.
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Abstract
Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.
Medical subject headings
- Antigens, T-Independent
- B-Lymphocytes
- Bacteremia
- Lymphocyte Activation
- Pneumococcal Infections
- Streptococcus pneumoniae