Chemical alignment of DNA origami to block copolymer patterned arrays of 5 nm gold nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21473607.
- Also identified by DOI 10.1021/nl200306w.
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Abstract
We have used block copolymer patterned arrays of 5 nm gold nanoparticles (AuNPs) for chemically aligned surface attachment of DNA origami. Addition of single-stranded DNA-thiol to AuNPs allowed a base paired attachment of sticky end modified DNA origami. Results indicate a stable, selective attachment between the DNA origami and ssDNA modified AuNPs. Yield data showed 74% of AuNP binding sites forming an attachment with a DNA origami rectangle, and control surfaces showed less than 0.5% nonspecific adsorption.
Medical subject headings
- DNA
- Gold
- Metal Nanoparticles
- Nanotechnology
- Polymers