Blocking HIF1α activity eliminates hematological cancer stem cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 21474097.
- Also identified by DOI 10.1016/j.stem.2011.03.006.
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Abstract
Selective targeting of cancer stem cells (CSCs) has the potential to prevent cancer relapse. Wang et al. (2011) report that hypoxia-inducible factor 1α (HIF1α) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1α activity eliminates lymphoma and human acute myeloid leukemia (AML) CSCs.