Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21483653.
- Also identified by DOI 10.1371/journal.pone.0018616 and PMC identifier 3071738.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton.
Medical subject headings
- Drosophila melanogaster
- Embryo, Nonmammalian
- Epithelial Cells
- Glycogen Synthase Kinase 3
- Protein Kinase C